Biosynthesis of Guanidinoacetic Acid in Isolated Renal Tubules
نویسندگان
چکیده
منابع مشابه
Biosynthesis of guanidinoacetic acid in isolated renal tubules.
Guanidinoacetic acid, a precursor of creatine, is an essential substrate for muscle energy metabolism. Since guanidinoacetic acid has been reported to be synthesized from arginine and glycine by glycine amidinotransferase (transamidinase) in kidney homogenates or slices, the purpose of this study was to provide evidence of guanidinoacetic acid synthesis in isolated tubules from rat kidneys, and...
متن کاملPerfusion of isolated renal tubules.
The metlhodls usedl for perftusinig isolatedi renal tul)ules are generally clifferent from microptuncture, as are the prob)lems encounteredl. Altlhotuglh I will concentrate maiinly on the teclhnical aslpects of perfuision, it seems to me most important to evaluate to wlhat extent the restults are p)ertinent to the stt(ly of kidney function. Are the tubules still "alive?' Are they still fuinctio...
متن کاملby isolated rat renal tubules
1. The effect of glucocorticoids on the deiodination of thyroxine (T,) to 3,5,3’-trbiodothyronine (T,) was studied in rat renal tubules prepared by collagenase digestion. 2. In short-term (6 h) experiments, cortisol and dexamethasone inhibited the conversion of T, into T, at concentrations of 2 x lo-, moll1 and 2 x mol/l respectively. The inhibition by cortisol and dexamethasone was time depend...
متن کاملDivalent anion transport in isolated renal tubules.
Inorganic phosphate and sulfate are the major divalent anions in biological fluids at physiological pH. The isolated perfused renal tubule technique has been used to address a number of questions about their renal transport; the purpose of this review is to summarize this information. Initial studies addressed traditional questions about the direction and segmental localization of phosphate and...
متن کاملPaths of Transtubular Water Flow in Isolated Renal Collecting Tubules
The cells of perfused rabbit collecting tubules swell and the intercellular spaces widen during osmotic flow of water from lumen to bath induced by antidiuretic hormone (ADH). Ouabain had no influence on these changes. In the absence of net water flow intercellular width was unaffected when tubules were swollen in hypotonic external media. Therefore, during ADH-induced flow widening of intercel...
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ژورنال
عنوان ژورنال: Clinical Chemistry and Laboratory Medicine
سال: 1992
ISSN: 1434-6621,1437-4331
DOI: 10.1515/cclm.1992.30.6.325